Boards of Nursing (BONs) exist in all 50 states, the District of Columbia, American Samoa, Guam, the Northern Mariana Islands, and the Virgin Islands. Similar entities may also exist for different regions. The mission of BONs is the protection of the public through the regulation of nursing practice. BONs put into practice state/region regulations for nurses that, among other things, lay out the requirements for licensure and define the scope of nursing practice in that state/region. It can be a valuable exercise to compare regulations among various state/regional boards of nursing. Doing so can help share insights that could be useful should there be future changes in a state/region. In addition, nurses may find the need to be licensed in multiple states or regions. To Prepare: Review the Resources and reflect on the mission of state/regional boards of nursing as the protection of the public through the regulation of nursing practice. Consider how key regulations may impact nursing practice. Review key regulations for nursing practice of your states/regions board of nursing and those of at least one other state/region and select at least two APRN regulations to focus on for this Discussion.